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The electrochemical oxidation of tryptophan was studied at the carbon ionic liquid electrode (CILE) modified with gold nanoparticle (GNP). This electrode has a stable and excellent response toward tryptophan. The oxidation of tryptophan at a GNP\CILE in phosphate buffer solution (pH=7) appears to be chemically irreversible at potential of 0.65 V vs Ag\AgCl. Comparative experiments were carried out using carbon paste electrode (CPE) and glassy carbon electrode (GCE). Under optimal experimental conditions, the calibration curve was linear in the tryptophan concentration range from 5 to 900μM with an excellent correlation coefficient (0.9955). The limit of detection was 4μM. The results indicate that contrary to many other electrodes, the oxidation of tryptophan on GNP\CILE does not result in electrode fouling.<\div>

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