توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Novel Ion Selective Electrode for Determination of Pregabalin in Pharmaceutical Dosage Form and Plasma
اطلاعات انتشار: Analytical & Bioanalytical Electrochemistry، چهارم،شماره۵، Oct ۲۰۱۲، سال
تعداد صفحات: ۱۱
Ion selective electrode technique was developed for determination of pregabalin. The key to construct such an electrode is to produce a sensitive and selective membrane that responds to a particular ionic species. Such membrane is usually prepared by in corporating an appropriate ion exchanger and solvent mediator into a poly (vinyl chloride) or (PVC) membrane matrix. The present work originates from the fact that pregabalin behaves as a cation in 0.1 N HCl solution and forms a precipitate with anionic potassium tetrakis p–chlorophenyl borate which used in fabrication of the membrane sensor. The potentiometric response was linear with constant slope over a drug concentration range of 10–6–10–3 M with slope of 53±1 mV\decade .The developed method was applied successfully for the determination of pregabalin in the pure powder form, pharmaceutical formulation and in spiked human plasma without any interference.
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