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۱Anti–Lipidaemic Effect of Kola Pod Exract on Wistar Albino Rats Fed with High Fat Diet
اطلاعات انتشار: World Applied Sciences Journal، سي و يكم،شماره۹، ۲۰۱۴، سال
تعداد صفحات: ۴
The anti–lipidaemic profiles of kola pod extract on wistar albino rats were assayed. Twenty four (24) apparently healthy male albino wistar rats with mean weight of 1.50±0.60kg were used. The rats were divided into four different groups (I–IV) of six (6) rats each. Group I rats were fed with normal feed only (morning and evening for seven days). Group II rats were fed with 10mg\ml of high fat diet (morning and evening for seven days).Group III rats were fed orally with10mg\ml of high fat diet for 7days (morning and evening). They were later on administered orally with 5mg\kg of atorvastatin drug for the following three days (once each day). Group IV rats were also fed orally with 10mg\ml of high fat diet for seven days (morning and evening) and wereadministered orally with 5mg\kg of kola pod extract for the following three days (once daily). The results showed that group 2 rats fed with 10mg\ml of high fat diet recorded the highest and lowest levels of low density lipoprotein cholesterol and high density lipoprotein cholesterol respectively when compared to that of group 1 (fed with normal feed). Groups 3 and 4 rats treated with 5mg\kg of standard drug (atorvastatin) and 10mg\kg of kola pod extract significantly reduced (p0.05) the LDL cholesterol molecule and consequently increased the HDL cholesterol molecule thereby showing the anti–lipidaemic properties of the water pod kola extract and that of the standard drug atorvastatin. Groups 3 and 4 rats also significantly reduced (p0.05) the concentrations of total cholesterol and triacylglycerol compared to that of control group rats (group1).
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