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۱Effect of Methanol Leaf and Fruit Extracts of Kigelia Africana on Some Biochemical Parameters of Normal Albino Rats
نویسنده(ها): ، ، ، ، ، ، ،
اطلاعات انتشار: World Applied Sciences Journal، سي و يكم،شماره۱۰، ۲۰۱۴، سال
تعداد صفحات: ۶
This study was aimed at evaluate the effect of methanol leaf and fruit extracts of Kigelia africana on normal rats. The catalase, vitamin C, protein level, total cholesterol, High Density Lipoprotein, Low Density Lipoprotein, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Malondialdehyde (MDA) concentration were determined. The experimental design comprises of twenty rats divided into four groups offive rats each. Group I served as a control while group II received 2.5mg\kg of glibenclamide, group III received 500mg\kg methanol leaf extract of Kigelia africana and group IV received 100mg\kg methanol fruit extract of Kigelia africana. The result showed a significant (p0.05) difference in protein level and vitamin C concentration in groups III and IV when compared with group I and group II. For total cholesterol, ALT and MDA concentration, a significant (p0.05) decrease in the treated groups (II, III and IV) was observed when compared to the normal (group I). Significant (p0.05) increase was observed in LDL concentration in group II when compared to group I, III and IV. There was no significant (p0.05) difference in HDL, AST and catalase for the different groups. The extracts showed significant reduction in, AST and lipid peroxidation (MDA), serumcholesterol as well as low density lipoprotein. The results obtained, suggest that methanol leaf and fruit extracts of K. africana could be meaningfully employed in maintaining and stabilizing normal metabolic state in normal organisms.
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