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۱Susceptibility Pattern of Extended Spectrum –lactamases Positive Escherichia coli isolated from a Tertiary Care Hospital of Peshawar, Pakistan
اطلاعات انتشار: World Applied Sciences Journal، سي ام،شماره۳، ۲۰۱۴، سال
تعداد صفحات: ۶
The emergences of extended spectrum –lactamases (ESBLs) are on the rise inhospital settings across the world. This study was carried out in order to isolate and identify the ESBLs producing Escherichia coli in the urine samples and to also find antibiotics susceptibility pattern in the clinical isolates. E. coli is the most common pathogen isolated from urine that exhibit the production of ESBLs that hydrolyse oxyimino beta lactam drugs and challenge the management of infections. A total of 195 urine samples were collected from the UTI suspected patients admitted at Lady Reading hospital, a tertiary care unit in Peshawar, Khyber Pakhtoonkhawa (KPK), Pakistan. The organisms were isolated, morphologically screened and biochemical characterized following standard microbial protocols. The isolated E. coli were screened for ESBLs production by double disk synergy method. Out of 68 positive samples 58 (85.2%) were Escherichia coli while, Streptococcus faecalis6 (8.8%), Enterobacteraerogens 2 (2.9%), Staphylococcus epidermidis1 (1.4%) and Proteus mirabilis 1 (1.4%) were also identified. Thirty eight out of 58 E. coli samples were identified as ESBLs producers. Frequency of ESBLs producer E. coli was high in females 24 (63.2%) in comparison to males 14 (36.8%). Furthermore, prevalence of ESBLs producing E. coli was high (47.3%) in age group >50 years. ESBLs producing E. coli were multi drug resistant. Finally,Meropenem, Tazobactum+Pipracilline, Salbactum+Cefaperazone and Amikacin are treatment of choice for urinary tract infections caused by ESBLs producing E. coli.
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