مقالههای 5Mehdi Asghari–Vostakolaei
توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقالههای نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده میشوند.
۱PLLA\HA Nano composite scaffolds for stem cell proliferation and differentiation in tissue engineering
نویسنده(ها): Fariba Mansourizadeh، Asadollah Asadi، Shahrbanoo Oryan، Ali Nematollahzadeh، Masoumeh Dodel، 5Mehdi Asghari–Vostakolaei
اطلاعات انتشار: Molecular Biology Research Communications، دوم،شماره۱-۲،۲۰۱۳ ، سال ۰
تعداد صفحات: ۱۰
Due to their mulitpotency, Mesenchymal stem cells (MSCs), have the ability to proliferate and differentiate into multiple mesodermal tissues. The aim of this study was to isolate MSCs from human Umbilical Cord (hUCMSCs) to determine their osteogenic potential on nanofibrous scaffolds. To this end, Poly (L–lactic acid) (PLLA)\Nano hydroxyapatite (HA) composite nanofibrous scaffolds were prepared by electrospinning. The structure and morphology of the scaffolds were investigated using scanning electron microscopy. Human mesenchymal stem cells (MSCs) were isolated from the umbilical cords and cultured in the PLLA\HA scaffold. The viability and proliferation of the cells was then determined by an MTT assay. Cellular adhesion, proliferation and osteogenic differentiation were assessed in these constructs using a range of histological and microscopic techniques. The osteogenesis assays indicated the superiority of nanofibrous scaffolds in supporting MSCs undergoing bone differentiation. Collectively, the bone construct prepared with PLLA\HA scaffold and proliferated MSCs would be a suitable candidate for use in bone regenerative medicine.
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