توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱New tigliane–type diterpenoids from Euphorbia aellenii Rech. f. with immunomodulatory activity
اطلاعات انتشار: Research in Pharmaceutical Sciences، ششم،شماره۱(پياپي ۱۱)، ۲۰۱۱، سال
تعداد صفحات: ۸
The cytotoxic chloroform fraction of Euphorbia aellenii Rech. F. (Euphorbiaceae) afforded two new phorbol diterpenoids: 4–deoxy–4α–phorbol–12–(2,3–dimethyl) butyrate–13–isobutyrate and 17–hydroxy–4–deoxy–4α–phorbol–12–(2,3–dimethyl) butyrate–13–isobutyrate. Their structures were elucidated by NMR and other spectroscopic methods. The immunomodulating potentials of the isolated compounds were tested using standard proliferation and chemiluminescence assays. Compound 2 showed moderate inhibitory activity against both T–cell proliferation and reactive oxygen species (ROS) production in whole blood with IC50 of 14.0 ± 0.57 and 44.1 ± 3.8 μg\ml, respectively, while compound 1 was relatively inactive with IC50 >50 μg\mL for T–cell proliferation, and >100 μg\mL for ROS.
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