توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱اندازه گیری رابطه آستانه تحریک و فاصله در تحریک الکتریکی سلول های عصبی با استفاده از تکنیک تعامل در پریود بازگشت
نویسنده(ها): ، ،
اطلاعات انتشار: چهاردهمین کنفرانس مهندسی پزشکی ایران، سال
تعداد صفحات: ۵
For more than a century, electrical stimulation of neural tissue has been in use experimentally and clinically for a wide range of purposes. In many applications of electrical stimulation, it is important to know the spatial extent of neural activation in response to the stimulation. The refractory interaction technique is a method that exploits the interaction between the regions of activation produced by two electrodes when the second stimulus is delivered while neurons in the region activated by the first electrode are in their refractory phase. We proposed a new method to estimate the current–distance relationship based on the refractory interaction technique. We evaluated this method using computer–based simulations of electrical stimulation and demonstrated the applicability and accuracy of the method for measuring the spatial extent of activation.

۲Contribution of BK Channels in the firing activity of Purkinje Cells
نویسنده(ها): ، ، ،
اطلاعات انتشار: هجدهمین کنفرانس مهندسی پزشکی ایران، سال
تعداد صفحات: ۴
BK channels are large–conductance voltage and Ca2+ –activated K+ channels available on the membrane ofmany types of neurons including cerebellar Purkinje cells. The role of these channels on electrophysiological behavior of Purkinje cells has been investigated in several experimental studies, including those that used Iberiotoxin as BK–specific channel blocker. However, these studies have not led to a conclusion about the role of BK channels. In this study, two realistic models of Purkinje cell with and without dendritic branches were used to investigate the functional contribution of BK channel currents to the firing activity of Purkinje cells. The results obtained from these models indicate that Purkinje cell spiking rate was slightly dependent on BK channelconductance. Block of the BK channel had no significant effect on the action potentials amplitude, but increased the duration of action potentials and the AHP amplitude.<\div>
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