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۱In vitro anti–Candida activity of Ficus lyrata L. ethyl acetate latex extract and Nystatin on clinical Isolatesand Standard strains of Candida albicans
اطلاعات انتشار: هفتمین همایش بیوتکنولوژی جمهوری اسلامی ایران، سال
تعداد صفحات: ۸
In this study, the antimicrobial activity of ethyl acetate latex extract of Ficus lyrata L. and Nystatin on 65clinical isolates of Candida albicans from Vulvovaginal candidiasis and standard strain of C.albicans ATCC5027 were studied. The plant extract was obtained from Iranian commercial company. Inhibitory effects of thecrude extract analyzed by using the disk diffusion technique (Bauer et al., 1966). The obtained results showedthat Ficus lyrata L. extract has inhibitory effect on clinical isolates and type strain of C.albicans in lowerconcentrations than Nystatin drug with the diameters of inhibition zones ranging from 22 to 26 mm and 30 to 32for clinical isolates and standard strains of C.albicans, respectively. The diameter of inhibition zones forNystatin was between 16 to 20 mm and 21 to 24 mm for standard strain and clinical isolates of C.albicans,respectively. Based on the data analysis (Macro dilution broth method), the best MIC of Ficus lyrata L. ethylacetate latex extract on clinical isolates and type strain of C.albicans were 25 mg\ml and 2.5 mg\ml,respectively. The best MIC of Nystatin on clinical isolates and type strain of C.albicans were 36 mg\ml but MICof combination of both showed more potency than Nystatin alone (0.05mg\ml), which is a synergistic effect.The GC\MS analysis of latex showed that extract contains alkaloids, flavonoids, phenols, Tannins, terpenoid.The present study forms the basis for further investigations to isolate active components, elucidated thestructures and evaluates them against wider range of microbial strains with the goal to find new the therapeuticprinciples.<\div>

۲In vitro antimicrobial activity of Urtica dioica L. extract againstAcne–inducing bacteria
اطلاعات انتشار: هفتمین همایش بیوتکنولوژی جمهوری اسلامی ایران، سال
تعداد صفحات: ۷
Objective: Bacterial skin infections are the 28th most common diagnosis in hospitalized patients. Propionibacterium acnesand Staphylococcus epidermidis have been recognized as pus–forming Bacteria triggering an inflammation in acne. Acnevulgaris is characterized as a superficial disease that affects the hair follicles and oil secreting glands of the skin. The presentstudy was conducted to evaluate antimicrobial activities of native plant (Urtica dioica L.) against these etiologic agents ofacne vulgaris.Methods: Ethanolic: extracts of Urtica dioica L. (Leaves) were tested for antimicrobial activities by disc diffusion and brothdilution methods. The results from the disc diffusion method showed that native extract could inhibit the growth ofPropionibacterium acnes. Based on a broth dilution method, the U.dioica extract had the greatest antimicrobial effect.Results: The MIC values were the same (0.12 mg\ml) for both bacterial species and the MBC values were 1.25 and 0.486mg\ml against Propionibacterium acnes and Staphylococcus epidermidis, respectively.Conclusion: Phytochemical screening of U.dioica revealed the presence of alkaloid which could be responsible for activity.In conclusion, our data indicated that U.dioica extract had a strong inhibitory effect on Propionibacterium acnes andStaphylococcus epidermidis.<\div>
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