توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Evaluation of relationship between HNF–1α and GLP–1R polymorphisms and type 2 diabetes in a population living in northeast of Iran
اطلاعات انتشار: Journal of Cell and Molecular Research، پنجم،شماره۲، ۲۰۱۳، سال
تعداد صفحات: ۶
The prevalence of type 2 diabetes mellitus (T2DM) is rising dramatically in the Middle East, especially in the Islamic Republic of Iran, but the genetic basis of type 2 diabetes in Iran is poorly understood. Polymorphisms of hepatocyte nuclear factor–1α (HNF–1α) and glucagon–like peptide–1 receptor (GLP–1R) genes showed association with type 2 diabetes in several ethnic groups. In this study, we evaluated whether these markers confer susceptibility to T2DM in a diabetic population living in Mashhad (northeast of Iran). Genotyping of Ala98Val (HNF–1α) and Thr149Met (GLP–1R) was done by the restriction fragment length polymorphism–PCR (RFLP–PCR) method in the following groups: 1) early–onset diabetes (age at onset ≤ 35 years); 2) late–onset diabetes (age at onset > 35 years); and 3) control. Our results showed that CT (Ala\Val) genotype of HNF–1α was higher in the early–onset type 2 diabetic group compared to the controls but difference was not significant. We did not find the GLP–1R Thr149Met mutation in all participants. The prevalence of the HNF–1α (Ala98Val) and (GLP–1R) Thr149Met mutations has not been previously reported in Iranian participants. We conclude that these mutations are not a common cause of T2DM in our studied population.
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