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۱Protective Effect of Artichoke (Cynara scolymus L.) Leaves and Pulp Extracts Against Carbon Tetrachloride–Induced Acute Hepatotoxicity in Rats
نویسنده(ها): ،
اطلاعات انتشار: World Applied Sciences Journal، سي و دوم،شماره۶، ۲۰۱۴، سال
تعداد صفحات: ۱۱
The present study aimed to detect qualitatively the chemical constituents of aqueous extracts of Artichoke leaves (ALE) and pulp (APE) and to assess their effects against carbon tetrachloride (CCl4)–induced acute hepatotoxicity in rats. Forty nine male Sprague Dawley rats were randomized into the following 7 groups: the normal control (–ve control), the model (+ve control), the standard (silymarin treated) and the other 4 pretreated groups by ALE and APE at low (200 mg\kg) and high (400 mg\kg) doses from each extract. Silymarin (50 mg\kg) and the plant extracts were orally given by stomach tube to rats in daily doses for 6 weeks. CCl4 was subcutaneously injected with 2 ml\kg to the model, the standard and the 4 pretreated groups during the last week of experiment to induce acute hepatotoxicity. Rats were weighed and weight gains were calculated. Blood samples were collected for separating the serum which used for biochemical analyses. Halve of livers of sacrificed rats was taken to assay the activity of hepatic tissue antioxidant enzymes and the other halve was used for histopathological examination. The results showed that both ALE and APE contain flavonoids, alkaloids, glycosides, saponins and tannins, but they were devoid of resins and triterpenes. Oral administration of ALE and APE to CCl4–intoxicated rats significantly increased the body weight gain, decreased the elevated serum levels of liver enzymes AST, ALT and ALP, total cholesterol, triglycerides, low density lipoprotein and total bilirubin and increased serum level of total proteins. There were also significant increases in the activity of tissue superoxide dismutase, glutathione peroxidase and catalase antioxidant enzymes accompanied with partial mitigation of histopathological lesions induced by CCl4 in the liver. The results denoted that ALE and APE have hepatoprotective, hypolipidemic and antioxidant effects and relatively alleviate the degenerative changes induced by CCl4 in the liver of rats. This study recommends that intake of edible parts of Artichoke in food or its use as herbal tea may be beneficial for patients suffering from liver diseases due to oxidative stress. Moreover, isolation of bioactive constituents of Artichoke plant is necessary to search for safe natural agents to be developed for therapy instead of chemically synthesized drugs which are usually accompanied by deleterious side effects.
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