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۱Effect of Magnesium Sulfate on Hemodynamic Changes During Sternotomy and Laryngoscopy in Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial
اطلاعات انتشار: Academic Journal of Surgery، سوم،شماره۱-۲، ۲۰۱۶، سال
تعداد صفحات: ۵
Background: This study was designed to evaluate the effectiveness of low and high dose magnesium sulfate in reducing pressure responses to laryngoscopy and sternotomy.Methods: A total of 90 patients were assigned into three groups. The patients in Group L received a 20 mg\kg bolus dose of magnesium sulfate 3 minutes before intubation followed by an infusion of magnesium sulfate (10 mg\kg\h) in contrast to 40 mg\kg of magnesium sulfate followed by an infusion of 20 mg\kg\h magnesium sulfate administered to Group H. Patients in Group P received saline as placebo. Heart rate and mean arterial pressure (MAP) recorded at the baseline were noted down again before intubation and 30 seconds, 2 and 4 minutes after intubation and 1 minute before, and 30 seconds, 2 and 4 minutes after sternotomy.Results: MAP in Groups L and H compared to Group P was significantly lower, after intubation (P = 0.0040). The difference between MAP in Groups L and H was only statistically significant 30 seconds after intubation. MAP 30 seconds and 2 minutes after sternotomy was statistically different between Groups L and H compared to Group P. The difference between Groups H and P was only statistically significant before sternotomy and 4 minutes after sternotomy (P = 0.0001).Conclusions: A low dose magnesium sulfate attenuates the hemodynamic response to laryngoscopy and sternotomy in coronary artery bypass graft surgery.
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