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۱Potentiometric Method for the Determination of Lamivudine and Dothiepin Hydrochloride in Pharmaceutical Preparations
نویسنده(ها): ، ، ،
اطلاعات انتشار: Analytical & Bioanalytical Electrochemistry، پنجم،شماره۲، Apr ۲۰۱۳، سال
تعداد صفحات: ۱۴
A simple and accurate potentiometric titration method for the determination of lamivudine and dothiepin hydrochloride is developed. For this purpose, two N bromoimides, viz., N–bromosuccinimide (NBS) and N–bromophthalimide (NBP) were used as titrants for determination of the two drugs in acid medium and the end point is determined using a platinum indicator electrode. The method was successfully applied for the determination of two drugs in their pure state or pharmaceutical preparations with mean recovery values of 99.67–100.10 and 99.55–100.33% and relative standard deviations (RSD) were 0.16–0.38 and 0.29–0.58% for lamivudine and dothiepin hydrochloride, respectively. Statistical comparison of the results with official and reported methods showed excellent agreement.
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