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۱Evaluation of Male–Mediated Reproductive Toxicity Induced by Polyethylene Glycol in Mice
اطلاعات انتشار: World Applied Sciences Journal، سي و يكم،شماره۸، ۲۰۱۴، سال
تعداد صفحات: ۱۰
In the present work polyethylene glycol (PEG6000) was given orally by gavage to male mice at three different doses 50, 100 and 200 mg\kg\day for consecutive 5 days per week up to six successive weeks. 24hr of treatment, half number of the mice from all experimental groups was sacrificed. Epididymis and testes were collected to evaluate the reproductive toxicity of PEG6000. The other half of treated male mice was mated with untreated virgin female mice to evaluate male–mediated genotoxicity of PEG6000 on fetuses. The results illustrated that PEG6000 decreased sperm motility and count in a dose–dependent manner. However, PEG6000 resulted in an increased fraction of sperm with abnormal morphology or abnormal chromatin integrity measured by toluidine blue and acridine orange. Besides, PEG6000 exhibited an increase in the occurrence of chromosomal aberrations in spermatocytes of treated male and in liver cells of their fetuses. Furthermore, testicular alternation and reduction of DNA nuclear content in spermatogonia and spermatocytes were observed in PEG6000 treated mice. In conclusion, chronic exposure of PEG6000 induced male reproductive impairment which correlated with genetic damage of fetuses generated from mating treated paternal mice with untreated female mice.
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