مقالههای Akram Alizadeh
توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقالههای نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده میشوند.
نویسنده(ها): Sara Rigi، Abolhassan Sakhae، Azadeh Niknam Asl، Akram Alizadeh، Fatemeh Beigi، Mehdi Mehdizadeh، Majid Ketabi، Mansooreh Soleimani
اطلاعات انتشار: Journal of Applied Biotechnology Reports، اول،شماره۲، Spring ۲۰۱۴، سال ۰
تعداد صفحات: ۴
Coenzyme Q10 is a promising agent for neuroprotection in neurodegenerative diseases. Neuroprotective effects of Coenzyme Q10 demonstrated in some neurodegenerative diseases such as Parkinson, Alzheimer and etc. Hippocampus is home of these diseases. We assayed Coenzyme Q10 effects on Hippocampal injury model and our hypothesis is that Coenzyme Q10 has Neuroprotective effects in some neurodegenerative diseases via hippocampus. For this purpose 24 Balb\c mouse took in 4 groups: Control (Without any treatment), Vehicle (Treated with sesame oil as Coenzyme Q10 vehicle), Hyppocampal injury model (Treated with Trimethyltin chlorideneurotoxin, 2.5 mg per kg IP), and test (Treated with Coenzyme Q10 after Trimethyltin chloride injection, 10 mg per kg IP for 2 weeks). After two weeks brain harvested and hippocampus tissue assayed by Nissl and Tunnel staining. Hystological study showed significantly increase of normal cells and decrease of apoptotic cells in test group after Coenzyme Q10 treatment in hippocampus. This study showed Coenzyme Q10 has protective effects in hippocampus after injury and it seems that Neuroprotective effects of Coenzyme Q10 in some neurodegenerative diseases com from that.
نویسنده(ها): Fereshteh Mozaffarian، Shima Ababzadeh، Akram Alizadeh، Esmaeel Sharifi، Majid Katebi، Farzaneh Mohammadzadeh، Sara Soleimani Asl، Pegah Zoalfaghar، Mansooreh Soleimani
اطلاعات انتشار: Journal of Applied Biotechnology Reports، اول،شماره۳، Summer ۲۰۱۴، سال ۰
تعداد صفحات: ۴
Schizophrenia affects 1% of population. Neonatal ventral hippocampus lesion (NVHL) model of schizophrenia designed in 1993 by Lipska and is a widely studied developmental animal model of schizophrenia. NVHL rats mimic many of the symptoms of schizophrenia in detail. We studied this model in molecular level and reelin expression in it. Reelin is an extracellular matrix glycoprotein that regulates some processes in CNS development and reduces significantly in schizophrenia. For this study, animals (male pups) take into 3 groups: control, sham and experiment. The lesion made by injection of 0.3 µl. Isotonic Neurotoxin withstereotaxic surgery in age 7 day and body weight 11–15 gr. Social behavioral and stereotypic movement assessed in age 56 day then reelin expression in frontal cortex evaluated by western blotting. Behavioral analysis and histological studies demonstrated the schizophrenia model. Western blotting of reelin protein in frontal cortex and hippocampus show a decrease of reelin (P value: 0.012) in experimental group as compared to control and sham group. So, in the NVHL as a common and more similar model of schizophrenia reelin expression significantly decreases in frontal cortex and hippocampus that means this model in molecular pathways is similar to the disease.
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