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۱Is Urinary Interleukin–8 a Marker of Vesicoureteral Reflux in Children?
اطلاعات انتشار: Journal of pediatric nephrology، دوم،شماره۱، ۲۰۱۴ ، سال
تعداد صفحات: ۴
Introduction: Developing non–invasive but accurate methods to diagnose vesicoureteral reflux (VUR) is in progress. Cytokines, such as interleukin–8 (IL–8), are important mediators in inflammatory responses and are demonstrated to change during UTI and pyelonephritis, as well. Therefore, we attempted to evaluate the differences of IL–8 in children with UTI compared to children with and without VUR to assess if it can be hypothesized to be an appropriate diagnostic marker in children with VUR. Materials and Methods: We evaluated urine levels of IL–8 in 41 children aged 1 to 60 months who recovered from UTI for a minimum duration of 2–3 weeks. They were divided into 2groups: A and B (with and without VUR, respectively). Additionally, a group of normal children was considered as the control group (group C). Urine IL–8 levels were measured for the three groups and corrected for urine creatinine (Cr) (IL–8\Cr). Afterwards, they were compared using One–Way ANOVA test. Results: The mean IL–8\Cr level was 81.7 ± 90.1 in group A, 289.8±640.2 in group B, and 9.6 ± 12.2 in group C with no significant difference (p=0.056). Conclusions: Our finding suggests there is no significant difference in urine IL–8\Cr levels between patients with and without VUR and therefore, we cannot propose IL–8 as a diagnostic marker for VUR.
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