توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Ferula assa–foetida extracts protection on the detoxification enzymes and β–catenin in colon tumor
اطلاعات انتشار: اولین کنگره بین المللی در مسیر توسعه علوم کشاورزی و منابع طبیعی، سال
تعداد صفحات: ۷
The present study was aimed to investigate the chemopreventive potential of Ferula assa–foetida hydroalcoholic extract on 1,2 dimethylhydrazine (DMH) induced rat colon carcinogenesis by evaluating the detoxification enzymes (GST & CYP 450 ) and β–catenin protein level. Rats were randomly divided into six groups: a negative control group without DMH; control group with injected DMH and four groups receiving DMH +F. assa– foedita extract as chemopreventive group. The effects of the extracts were assessed by estimating the GST and CYP450. Moreover, the colonic β–catenin protein level was examined in colon tissues followed by histopathological analysis. The results showed that the administrations of F. assa–foedita hydroalcoholic extracts caused the chemopreventive effects against colon cancer incidence by modulating the DMH–metabolizing enzyme activities such as CYP450 and GST concomitant with decreased level of β–catenin protein. Histological observations of colon tissue indicating the decrease in the aberrant crypt foci (ACF) formations in the extract treated groups. These results prove the excellent efficacy of the herb at chemopreventive property, against DMH induced colon carcinogenesis.<\div>

۲Persian Golpar oils prevent acetaminophen induced liver injury through restoration of oxidative stress
اطلاعات انتشار: اولین کنگره بین المللی در مسیر توسعه علوم کشاورزی و منابع طبیعی، سال
تعداد صفحات: ۷
Acetaminophen (APAP) is widely used as analgesic and antipyretic drug, but at overdose, it caused to undesirable side effects particularly hepatic necrosis. The objective of the present study was to investigate the hepatoprotective potential of H.persicum essential oil (E.O) against acetaminophen induced toxicity in rats. 80 male Wistar rats were randomly distributed into four groups (n=5); in negative control group (NC), the DMSO was only i.p injected. In control group (C), the cetaminophen (500 mg\kg b.w) dissolved in 400 μl DMSO was i.p injected. In the treatment groups, the H.persicumo E.O (100 and 200 mg\kg b.w) was diluted in 400 μl DMSO and injected i.p immediately after acetaminophen administration. Then, the degree of hepatoprotection was measured using antioxidant assays of liver homogenate including lipid peroxidation, reduced glutathione content, ferric reducing ability of plasma (LP, GSH & FRAP) at 4, 8, 16 and 24 h after acetaminophen treatment. Histopathological study of the rat liver was also done. The data indicated that the toxic effect of acetaminophen was controlled significantly by H. persicum E.O through restoration of the oxidative stress and antioxidant parameters; LP, GSH and FRAP towards near normal values. Furthermore, histology of the liver sections of the rats treated with the oils showed the presence of normal hepatic tissue in comparison with APAP group. These results strongly supported that H. persicum E.O extract could be an appropriate candidate for the treatment of acetaminophen induced oxidative stress liver damages.<\div>
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