توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Biocompatilbility evaluation of a natural polymer–based scaffold
اطلاعات انتشار: کنفرانس بین المللی فرآورش پلیمرها، سال
تعداد صفحات: ۵
The key point in the success of a tissue engineering technique is to mimic the structural and functional properties of a native tissue. Many researchers’ efforts are on design and synthesis of basements which chemically and topographically resemble the extracellular matrix (ECM), the basement membrane of cells in the biological environment of the body. Collagen is the most abundant protein component of ECM and also a type of polymer with natural sources that is widely utilized to fabricate scaffolds. In this study, following our previous work in synthesizing two different structured collagen–based scaffolds, the biocompatibility of the scaffolds were investigated through seeding of two cell lines directly on the surface of scaffolds. The SEM micrographs confirmed the positive effects of the scaffold on cells outgrowth. Also the positive effect of fiber orientation on cell outgrowth organization was traced through SEM images. The cells’ attachment affinity was discussed in attachment assay results, the rate of cell proliferation was assessed using a quantitative method and was compared with the control samples. As an overall conclusion, it seems that the process of engineering the tissues via submicron\nano fibrous biopolymer scaffolds is a promising and flourishing method<\div>

۲Fabrication of a biopolymer fibrous scaffold for nerve tissue engineering
اطلاعات انتشار: کنفرانس بین المللی فرآورش پلیمرها، سال
تعداد صفحات: ۷
Nerve tissue engineering is one of the most promising methods in nerve tissue regeneration. The development of collagen scaffolds can potentially be used in many soft tissue engineering applications. Electrospinning is a polymer processing technique that utilizes an electric field to form fibers from a polymer solution or melt and allows the fabrication of nanofibrous non–woven structures. In this study an attempt was made to develop aligned and random electrospun, nanofibrous scaffolds using collagen. Different parameters in electrospinning process such as solution viscosity, electric field strength, solution flow rate and nozzle to target distance were assessed and optimized to achieve the appropriate scaffold characteristics. To analyze the effect of solution viscosity on fiber diameter, electrospinning was performed using 18, 15, 10 and 7% w\v concentrations. In order to detect the effect of electric field strength, three different experiments were run with electric field strength of 20, 15 and 10 kV, while the other parameters were kept unchanged. Regarding the adjusted electric field, three solution flow rates of 0.2, 0.5 and 0.7 ml\h were set for solution flow rate. Nozzle to target distance parameter was also assessed through three experiments with three distances of 13, 15 and 20 cm. The effects of all these four parameters were traced through the SEM micrographs.<\div>
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