توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Oxford–MEST classification in IgA nephropathy patients: A report from Iran
اطلاعات انتشار: Journal of nephropathology، اول،شماره۱، Apr ۲۰۱۲، سال
تعداد صفحات: ۱۲
Background: There is a limited knowledge about the morphological features of IgA nephropathy (IgAN)in the middle east region.Objectives: The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our laboratory.Patients and Methods: At this work, an observational study reported which was conducted on IgAN patients using the Oxford–MEST classification system.Results: In this survey, of 102 patients 71.6 % were male. The mean age of the patients was 37.7 13.6 years. Morphologic variables of MEST classification was as follows; M1: 90.2 %, E: 32 %, S: 67 % also,T in grads I and II were in 30% and 19% respectively, while 51% were in grade zero. A significant difference was observed in segmental glomerulosclerosis (P=0.003) and interstitial fibrosis\tubular atrophy frequency distribution (P= 0.045), between males and females . Furthermore, it was found that mesangial hypercellularity was more prevalent in yonger patients. Moreover, there was a significant correlation between serum creatinine and crescents (P0.001). There was also significant correlation of serum creatinine with segmental glomerulosclerosis (P0.001).Conclusions: Higher prevalence of segmental glomerulosclerosis and interstitial fibrosis\ tubular atrophy, as the two of, four variables of Oxford–MEST classification of IgAN in male patients further attests that male gender is a risk factor in this disease.In this study the significant correlation between serum creatinine and crescent was in an agreement with previous studies and suggests for the probable accomodation of extracapillary proliferation as a new variable in MEST system.

۲Erythropoietin ameliorates genetamicin–induced renal toxicity: A biochemical and histopathological study
اطلاعات انتشار: Journal of nephropathology، اول،شماره۲، Jul ۲۰۱۲، سال
تعداد صفحات: ۸
Background: Investigations have attempted to modify the outcome of tubular injury by either ameliorating renal tubular damage or promoting tubular regeneration in the case of acute tubular necrosis.Objectives: We investigated the protective effect of Eprex an erythropoietin analogue on tubular injury induced by gentamicin (GM).Materials and Methods: Forty male Wistar rats were randomly divided into four groups. In group 1,rats were served as a sham group. In group 2, rats were injected intraperitoneally with 100 mg\kg of GM for 10 consecutive days (positive control group) and then were sacrificed. In group 3, rats received GM for 10 days then Eprex 100U\kg was injected intraperitoneally for the next 10 days and then they were sacrificed at the day 20th. In group 4 rats were injected a combination of GM (80 mg\kg) and Eprex 100U\kg intraperitoneally for 10 days and then were sacrificed.Results: The results indicated that, Eprex prevented the increase in serum creatinine (Cr) and blood urea nitrogen (BUN). The effect of Eprex on damage score, showed that co–administration of GM and Eprex (group 3 and 4) reduced the kidney tissue damage compared to positive control group (P0.05). This result indicat that Eprex potentially can reduce or prevent the kidney tissue damage. Conclusions: Ameliorative effect of Eprex when the drug was given in combination with GM and also when the drug was applied after GM–induced tubular damage, revealed the renoprotective potency of Eprex. Eprex is a promising drug to prevent or attenuate tubular damage induced by GM or other nephrotoxic agents which act through the same mechanisms as gentamicin.

۳Lipoprotein(a), type 2 diabetes and nephropathy; the mystery continues
نویسنده(ها):
اطلاعات انتشار: Journal of nephropathology، اول،شماره۳، oct ۲۰۱۲، سال
تعداد صفحات: ۴

۴Nephrotoxicity and hepatotoxicity evaluation of Crocus sativus stigmas in neonates of nursing mice
اطلاعات انتشار: Journal of nephropathology، سوم،شماره۲، Apr ۲۰۱۴، سال
تعداد صفحات: ۵
Background: Crocus sativus, known as saffron crocus, is best known for the spice saffron.Saffron use spans more than 3500 years, however, its toxicity on neonates during lactationhas not yet evaluated.Objectives: This study was aimed to examine the acute toxicity of saffron on adult mice and itsnephrotoxicity and hepatotoxicity on neonates of lactating mothers that used saffron duringlactation.Materials and Methods: In this experimental study, following acute toxicity evaluation, 32pregnant mice were randomly designated into four equal groups. Following delivery, themothers of groups 1 to 4 were administered orally (by gavage) normal saline (control group),500, 1000 or 2000 mg\kg\day of saffron for three weeks, respectively. The newborns’kidney and liver parameters were assessed at the end of the study for possible nephrotoxicityand hepatotoxicity evaluation. The kidney and liver tissue samples of newborns werehistopathologically studied after staining with Hematoxylin & Eosin. Data were analyzedusing ANOVA and Scheffe’s testsResults: The LD50 value of saffron was calculated to be 4120±556 mg\kg in mice. To evaluatelactating toxicity, saffron was administered orally to the mothers once daily for 21 days, afterdelivery, during lactating period. Saffron increased serum urea nitrogen (p 0.05). Histologicalstudies indicated that saffron did not have any toxic effect on liver, however, histopathologychanges were seen in the kidney of neonates.Conclusions: From the results of present study, it might be concluded that saffron is a nearlysafe spice, however, nursing mothers should avoid high doses of this spice.

۵Clinicopathological correlations in lupus nephritis; a single center experience
اطلاعات انتشار: Journal of nephropathology، سوم،شماره۳، Jul ۲۰۱۴، سال
تعداد صفحات: ۶
Background: Renal biopsies play an important role in the diagnosis, management and prognosis of patients with lupus nephritis (LN). Objectives: To determine the correlation between the pathological features of LN and the demographic, clinical and laboratory parameters. Patients and Methods: This retrospective study was conducted from 2008 to 2014 on all consecutive cases of biopsy–proven LN at a nephropathology laboratory in Iran. The demographic, clinical and laboratory data were obtained from patients’ files and the biopsy findings from the original biopsy request forms. Results: Of the 84 patients enrolled, 69 (82.2%) were females and 15 (17.8%) males. The mean age was 32.7±12 years. The mean serum creatinine was 1.5±0.94 mg\dl and the mean 24–h proteinuria, 1.6±1.9 grams. The majority of cases belonged to classes III and IV. The extracapillary proliferation was found in 42.86% of biopsies and endocapillary proliferation in 66.67% of biopsies. Patients of class IV–LN had a higher mean serum value of creatinine in comparison to class III–LN (2.19±1.09 versus 1.2±0.56 mg\dl; p= 0.0001). There was no significant difference of 24–h proteinuria between the two classes (p= 0.882). A significant association of serum creatinine with 24–h proteinuria (p= 0.041) was seen. Serum creatinine had significant positive correlation with activity percent (p 0.001), and chronicity percent (p= 0.006), and also with proportion of glomeruli with crescents (p 0.001). While there was a significant relationship of proteinuria with chronicity percent (p= 0.001), this association for activity percent was not significant (p= 0.094). Furthermore, the association of proteinuria with totally sclerotic glomeruli and proportion of crescents was not statistically significant (p= 0.186 and p= 0.0145 respectively). Conclusions: In conclusion, the results from our study on biopsy–proven cases of LN largely concur with the previously reported studies from Iran and other parts of the world.
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