مقالههای Azari M
توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقالههای نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده میشوند.
۱Effect of Ferula assafoetida on cytoplasmic membrane glucose transporter isotype–4 of C2C12 cell line
اطلاعات انتشار: International Journal of Medical Laboratory، اول،شماره۱، ۲۰۱۴، سال ۰
تعداد صفحات: ۸
Background and Aims: Ferula Assafoetida is an antioxidant plant which has long been used in Iranian traditional medicine. Recently, it has been reported to have hypoglycemic and hyperinsulinemic effects, but the molecular mechanism of this effect have not been sufficiently described. This study was a step to evaluate the molecular mechanism of Ferula assafoetida action as an antihyperglycemic agent. For this purpose, some signling pathways of the hypoglycemic effect of its extract using C2C12 mouse cell line were examined.Materials and Methods: C2C12 cells were differentiated in DMEM medium supplemented with 2% heat inactivated horse serum, and treated with 10 µg\ml extract of assafoetida in presence or absence of phosphoinositide 3–kinase (PI–3K) inhibitor. The concentration of Glucose transporter type 4 (GLUT4) in cytosol and cytoplasmic membrane were determined using SDS–polyacrylamide gel electrophoresis and western blotting analyses.Results: Data indicated that assafoetida treatment increases translocation of the GLUT4 to the cell membrane in C2C12 cell line via PI3K\Akt signaling pathway activation.Conclusion: our finding indicated that assafoetida has a potential antidiabetic effect and may be considered as antidiabetic drug.
اطلاعات انتشار: Poultry Science Journal، دوم،شماره۱، ۲۰۱۴، سال ۰
تعداد صفحات: ۱۱
Drug prescription errors are a common cause of adverse incidents and may lead to adverse outcomes, sometimes in subtle ways, being compounded by circumstances or further errors. Therefore, it is important that veterinarians issue the correct drug at the correct dose. Using two or more prescribed drugs may lead to drug interactions. Some drug interactions are very harmful and may have potential threats to the patient''s health that is called antagonism. In a survey study, medication errors of 750 prescriptions, including dosage errors and drug interactions were studied. The results indicated that 20.8% of prescriptions had at least one drug interaction. The most interactions were related to antibiotics (69.1%), Sulfonamides (46.7%), Methenamine (46.7%) and Florfenicol (20.2%). Analysis of dosage errors indicated that total drugs consumed by broilers in the summer are more than winter seasons. Based on these results, avoiding medication errors are important in the balanced prescribing of drugs and regular education of veterinary practitioners in a certain interval is needed.
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