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۱Caspase inhibition and natural neuron death
نویسنده(ها): ،
اطلاعات انتشار: چهارمین همایش ملی بیوتکنولوژی ایران، سال
تعداد صفحات: ۶
Programmed cell death (PCD) during which up to 50% of the neurons die in a certain period of time, occurs in the developing nervous system. Proteases, among them caspases, are known to be involved in cell death. To investigate if any specific protease(s) has a key role in PCD, chicken embryos were treated daily from E6–E9 with different protease inhibitors in this study. Among the inhibitors available in market, those for the caspase inhibition in general and for the inhibition of caspase 8, caspase 9 and calpain were used. Embryos were killed at E10 and neurons were counted in cilliary ganglia (CG). As expected, there was a significant increase in neuron numbers in CGs of embryos treated with a general caspase inhibitor. Interestingly, among the other CGs, there was a significant increase in neuron numbers only in those treated with caspase 9 inhibitor. These results suggest a key role of caspase 9 in the intracellular pathway of PCD.<\div>
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