توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Mean Platelet Volume: A Useful Marker in Reflux Nephropathy
اطلاعات انتشار: Journal of pediatric nephrology، دوم،شماره۴، ۲۰۱۴، سال
تعداد صفحات: ۳
Introduction: The inflammatory reaction caused by a pyelonephritis infection can result in renal injury or scarring, which is also termed reflux–related renal injury or reflux nephropathy. The importance of platelet changes is emphasized in some chronic diseases. In this study, the changes of mean platelet volume (MPV) and mean platelet count (MPC) were investigated in children with reflux nephropathy.Materials and Methods: In this case–control study, 107 females with vesicoureteral reflux (VUR) (grade 1 to 3) and reflux nephropathy and 107 females with VUR (grade 1 to 3) without reflux nephropathy were included. Demographics characteristics of the patients were recorded and laboratory parameters in the active phases of first pyelonephritis were evaluated.Results: MPC was higher in patients with reflux nephropathy than non–reflux nephropathy patients and MPV was lower in the patients with reflux nephropathy than patients without reflux nephropathy.Conclusions: MPV can be used as an indicator in diagnosis of reflux nephropathy in patients with VUR.

۲The Relationship Between Iron Deficiency Anemia and Reflux–Related Renal Injury in Infant and Children
اطلاعات انتشار: Journal of pediatric nephrology، سوم،شماره۲، ۲۰۱۵، سال
تعداد صفحات: ۴
Introduction: Anemia may be defined either quantitatively or physiologically. The diagnosis of anemia is determined by comparison of the patient''s hemoglobin level with age–specific and sex–specific normal values. The easiest quantitative definition of anemia is any hemoglobin or hematocrit value that is 2 standard deviations (SDs) (95% confidence limits) below the mean for age and gender. The aim of this study was to evaluate the relationship between anemia and reflux nephropathy in patients with vesicoureteral reflux. Material and Methods: This case–control study involved 260 children aged from 6 months to 2 years. They were divided into two groups of 130 children: the case group suffering from VUR with reflux nephropathy and the control group affected with VUR without reflux nephropathy .Results: Results of our study showed that the prevalence of anemia in the Reflux Nephropathy group was not considerably different than that of the control group.Conclusions: We concluded that there isn’t a direct correlation between anemia and reflux nephropathy in patients with vesicoureteral reflux.

۳Mean Platelet Volume as a Predictive Marker for Poor Prognosis of Acute Renal Failure in children
اطلاعات انتشار: Journal of pediatric nephrology، سوم،شماره۳، ۲۰۱۵، سال
تعداد صفحات: ۳
Introduction: Acute renal failure (ARF) is a clinical syndrome in which a sudden deterioration in renal function results in the inability of the kidneys to maintain fluid and electrolyte homeostasis. A classification system has been proposed to standardize the definition of acute kidney injury in adults. These criteria of risk, injury, failure, loss and end–stage renal disease were given the acronym of RIFLE. Our goal was to study the mean platelet volume (MPV) as a prognostic predictor of ARF in children. Mean platelet volume (MPV) is a machine–calculated measurement of the average size of platelets in blood and typically included in blood tests as part of CBC (Complete Blood Count). Since the average platelet size is larger when the body is producing increased numbers of platelets, MPV can be used to make inferences about platelet production in bone marrow or platelet destruction problems.Material and Methods: The records of 200 patients with ARF were investigated prospectively. Complete blood count including MPV, erythrocyte sedimentation rate, serum C–reactive protein and electrolytes of patients were measured and compared.Results: MPV values were low in loss (p=0.0012) and failure (p0.005). The sensitivity and specificity of MPV for the diagnosis of loss and failure were higher than those of the other inflammation markers. MPV8.2 fL was significantly associated with poor prognosis in renal functions.Conclusions: MPV is a fast and reliable measurement with considerable predictive value for prediction of prognosis in acute renal failure.

۴The Mean Platelet Volume in children with Pyelonephritis
اطلاعات انتشار: Journal of pediatric nephrology، چهارم،شماره۲، ۲۰۱۶، سال
تعداد صفحات: ۴
Introduction: The mean platelet volume (MPV) is a determinant of inflammation. The aim of the present study was to investigate the MPV levels in children with pyelonephritis and to evaluate the possible relationship between MPV and febrile UTI.Materials and Methods: In this prospective observational study, 82 patients with Pyelonephritis (group A) and 82 patients with viral gastroenteritis (group B) were enrolled from 20 Jun 2013 through 15 Jan 2014. The patients were divided into two groups according to the presence of pyelonephritis and viral gastroenteritis. The pyelonephritis group (A) included 82 patients and the acute gastroenteritis group (B) included 82 patients. Complete blood count (CBC) parameters were measured at admission. Routine biochemical tests were performed. Groups were compared according to different parameters.Results: A total of 164 patients were included from inpatients of Amir–Kabir Hospital. The mean platelet volume was lower in group (A) and it was associated with acute pyelonephritis (P =0 .003). The MPV (6.03 ± 0.26 fl vs. 9.06 ± 0.73 fl) was significantly lower in group (A), the platelet count (219.88–± 52.31vs. 184.09 ± 52.21) was significantly higher in group (A), and the WBC count (13.01± 3.43 vs. 8.30 ± 1.13) was significantly higher in group (A).Conclusions: MPV levels were significantly lower in children with pyelonephritis compared with controls. MPV can be used as a negative acute phase reactant in children with febrile UTI.
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