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۱Influence of Electrolytes Supplementation on Cardiac and Renal Functions after Prolonged Exercise in Male Rats
نویسنده(ها): ،
اطلاعات انتشار: World Applied Sciences Journal، بيست و سوم،شماره۱۰، ۲۰۱۳، سال
تعداد صفحات: ۹
Heavy sweating after prolonged exercise can cause body fluid losses and alteration of the body function. The purpose of this study was to identify whether electrolytes supplementation promoting rehydration following exercise induced dehydration in male rats. Animals assigned into four equal groups. GroupI served as control, GroupII animals practiced exercise through training program on treadmill,GroupIII animals exercised on treadmill then supplemented by Rehydran–n content dissolved in water. GroupIV animals exercised on treadmill and then supplemented by Rehydran–n content and (Magnesium + Calcium) citrate dissolved in water. After 6 weeks animals were slaughtered and the harvested serum was used to estimate creatine phosphokinase (CPK), lactate dehydrogenase (LDH) enzymes, kidney function (urea and creatinine), Na+, K+, Cl–, Mg2+, Ca2+, P ions and aldosterone. Also heart and kidney tissues were dissected out for histopathological examination. The results revealed an increase in CPK, LDH, urea and creatinine which may be due to oxidative stress.Rehydran–n or Rehydran–n and (Magnesium +Calcium) citrate treatment ameliorates these effects and these values decreased in groups III and IV. Na+, Cl– and Mg2+ decreased While K+, Ca2+ and P increased significantly in exercised group, electrolyte disorders happen. In group III fluid balance happen and Na+ and Cl– restored while K+ still increased. Magnesium and calcium ions increased significantly in group IV only. Group II showed cardiac and renal tissue damage. Aldosterone level decreased in group II while it increased in group III and IV. In conclusion the restoration of body fluid losses is necessary for optimal cardiac and renal functions during exercise. Assuming that rehydration strategy after exercise is necessary.
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