توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱The effects of technical and compositional variables on the size and release profile of bovine serum albumin from PLGA based particulate systems
اطلاعات انتشار: Research in Pharmaceutical Sciences، نهم،شماره۶(پياپي ۲۷)، ۲۰۱۴، سال
تعداد صفحات: ۱۴
Double emulsion solvent evaporation technique is one of the most attractive methods used to prepare micro and nanoparticles in pharmaceutical areas of interest, but because of the effects of many formulation factors on the size and release behavior of the fabricated particles, optimization of the formulation factors is needed. In this study various parameters including technical and compositional variables were considered to achieve an optimized formulation with desire characteristics especially size and the release profiles, using high shear homogenizer. In this regard, bovine serum albumin (BSA) was used as the model protein and double emulsion was formed with the addition of Tween 80 and Span 80 as surfactants for inner aqueous phase and oil phase, respectively. Hydroxypropyl beta cyclodextrin was used as protein stabilizer. After optimization steps, composite nanoparticles (core–shell) were made based on optimized formulation by hyaluronic acid as shell and poly lactic–co–glycolic acid (PLGA) as core material. Formulation of the BSA loaded PLGA nanoparticles using core shell strategy improved the release pattern of the BSA and diminished burst release. The final composite nanoparticles had the particle size of about 160 nm and 70 % of the loaded BSA was released during 14 days and the release data was better fitted to zero order release kinetics.

۲Physicochemical and rheological parameters changes for determining the quality of surimi and kamaboko produced by conventional, acid and alkaline solubilization process methods from common kilka (Clupeonella cultriventris caspia)
نویسنده(ها): ، ،
اطلاعات انتشار: IRANIAN JOURNAL OF FISHERIES SCIENCES، چهاردهم،شماره۴، Oct ۲۰۱۵، سال
تعداد صفحات: ۲۰
Physicochemical properties of surimi and kamaboko obtained of solubility in acid, alkaline and conventional methods were compared. The results indicated that the highest protein recovery was related to solubility in acid, alkaline and conventional methods, respectively. The highest removal of lipid and myoglobin was observed by solubility in alkali. Excretion of total pigment and sulfhydryl groups was not significantly different between solubility in alkali and acid methods. Whiteness of surimi prepared by acid method was more than the other two methods. Electrophoresis pattern in surimi produced by conventional method indicated loss of myofibril and sarcoplasmic proteins through the washing process. Solubility in acid and alkali methods showed myofibril proteins recovery along a part of the sarcoplasmic proteins and disintegration of myosin heavy chain. Physically, study of kamaboko showed that solubility in alkali generated features such as gel strength, expressible moisture, hardness, gumminess and elasticity was superior to the other two methods. About folding test and cohesiveness factor, there was no significant difference between solubility in alkali and conventional methods. In general, solubility in alkali method was better.
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