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۱Evaluation of LamB linear and conformational epitopes on the Vibrio harveyi
نویسنده(ها): ،
اطلاعات انتشار: کنفرانس بین المللی مهندسی و علوم کاربردی، سال
تعداد صفحات: ۱۵
Vibriosis is one of the most serious infectious diseases in fish and shellfish. However, due to the diversity of pathogens and their complicated serotypes, the progress in vaccine development against Vibriosis has been slow. LamB proteins (or maltoporins) are a family of OMPs. It forms a betabarrel composed of three monomers and ensures the transport of maltose and maltodextrin in Gram–negative bacteria reported that recombinant Aeromonas hydrophila outer membrane protein 48, which belongs to the maltoporin group of porins, induces a protective immune response against A. hydrophila and E. tarda. There has been no other report of immunological characteristics of LamB so far. Nowadays, bioinformatics is reliably working in biology researches. It could be harnessed in vaccine plan as well as epitope mapping drives. In the present study we exploit bioinformatic tools to introduce the best regions of LamB as antigenic determinants in order to design (a) novel construct (s) as vaccine or diagnostics.<\div>

۲Functional Exposed Amino Acids of LamB as a vaccine candidate for Vibriosis
نویسنده(ها): ،
اطلاعات انتشار: سومین کنفرانس بین المللی علوم و مهندسی، سال
تعداد صفحات: ۱۳
Vibriosis is one of the most serious infectious diseases in fish and shellfish. However, due to the diversity of pathogens and their complicated serotypes, the progress in vaccine development against Vibriosis has been slow. LamB proteins (or maltoporins) are a family of OMPs. It forms a betabarrel composed of three monomers and ensures the transport of maltose and maltodextrin in Gram–negative bacteria reported that recombinant Aeromonas hydrophila outer membrane protein 48, which belongs to the maltoporin group of porins, induces a protective immune response against A. hydrophila and E. tarda. Findings indicated that antibodies against LamB were protective, making this antigen a likely candidate for a vaccine. Early clinical trials demonstrated that recombinant LamB was immunogenic and well tolerated, even in subjects with a history of vibrio disease. The present study was designed to in silico resolving the major obstacles in the control or in prevention of vibrio diseases. We exploited bioinformatic tools to better understanding and characterizing the LamB structure and select appropriate regions as effective B cell epitops<\div>
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