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۱Effect of Coenzyme Q10 (ubiquinone) on hippocampal CA1 pyramidal cells following transient global ischemia\reperfusion in male wistar rat
اطلاعات انتشار: Journal of Pharmaceutical & Health Sciences، دوم،شماره۲، Winter ۲۰۱۴، سال
تعداد صفحات: ۸
Ischemia\Reperfusion (I\R)–induced cerebral injury has been reported as a leading cause of death and long–term disabilities. Hippocampus is an area which is more sensitive to be affected by I\R and hypoxic conditions. Coenzyme Q10 is a strong antioxidant which plays a role in membrane stabilization. This study aims to investigate the possible role of CoQ10 in ameliorating the histomorphological changes in the hippocampal CA1 pyramidal cells induced by cerebral I\R. Thirty six adult male wistar rats were divided into six groups, each group consisting of six rats, including control, ischemia, vehicle and CoQ10–treated (10, 50,100 mg\kg). In treatment groups, rats were orally administered CoQ10 during five days before and three days after I\R. Global cerebral ischemia was induced by bilateral common carotid arteries occlusion for about 20 minutes, followed by reperfusion. H&E and Nissl staining were utilized for some qualitative and quantitative studies. Then the histomorphological changes were measured by Image Tools 2 software. The data analysis showed a significant reduction in the number of CA1 pyramidal cells after I\R; whearas, no significant difference was seen in the number of cells in mentioned region between control and 100 mg\kg CoQ10–treated groups. The findings indicate the neurotrophic properties of CoQ10 and support the beneficial effects of CoQ10 as an adjuvant therapy in patients who have risk factor(s) of ischemic stroke.

۲Effect of Pentoxifylline on Histomorphological Changes of Kidney after Ecstasy (MDMA) Administration in Male Wistar Rat
اطلاعات انتشار: Journal of Pharmaceutical & Health Sciences، دوم،شماره۲، Winter ۲۰۱۴، سال
تعداد صفحات: ۱۰
Methylenedioxymethamphetamine (MDMA),the Ecstasy brand, leads to cell death in many tissues such as kidney because of its oxidative properties. The present study aimed to investigate the possible effects of pentoxifylline as a vasodilators on ecstasy induced renal damage. This experimental study was carried out in four groups of six male wistar rats weighing 250–300 g (n=24). The control group was kept under standard laboratory conditions. Ecstasy was injected as 7.5 mg\kg, q 2 h × 3 doses intraperitoneally (IP) in the treatment group. In PTX(PTX) treated group, 200 mg\kg of PTX was concurrently administered with the third dose of ecstasy injection and in vehicle group, normal saline was injected. The kidneys were evaluated for histomorphological changes by H&E and PAS stainings. Then the degrees of renal damage were scored by Image Tools Version 2 software. Although no significant differences in diameter and number of glomerular cells between control andPTX treated groups was detected, a significant difference was seen between vehicle and Ecstasy groups (P 0.05). Tubulointerstitial injury was seen in Ecstasy and vehicle groups but it had been decreased in PTX treated group. Findings of this study suggest that PTX can exert asignificant effect on improving the ecstasy induced renal tissue injuries.
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