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۱Novel PVC–free All–solid–state Ion–selective Electrode for Determination of Chlorhexidine in Pharmaceutical Formulations
نویسنده(ها):
اطلاعات انتشار: Analytical & Bioanalytical Electrochemistry، ششم،شماره۲، Apr ۲۰۱۴، سال
تعداد صفحات: ۱۳
The potentiometric response characteristics and analytical applications of a poly(vinyl chloride) (PVC)–free all–solid–state ion–selective electrode for chlorhexidine (CHX) are examined and compared to those of PVC–based solid–state electrode. The PVC–free electrode is prepared by direct incorporation of chlorhexidine–tetraphenyl borate (CHX–TPB) as a sensing element into a commercial nail varnish (NV) containing cellulose acetate propionate. The composite was applied onto a 3 mm diameter graphite disk–electrode. The electrode exhibited a Nernestian slope of 29 mV\decade in the concentration range from 10–5 to ≤10–3 mol\L with a detection limit of 4×10–6 mol\L. The electrode is independent of pH in the range from 3.6 to 7.9. Cationic inorganic ions showed negligible interference, whereas, a strong electrode response was observed for cetrimide and benzalkonium chloride with selectivity coefficients of 8.62 and 7.59 respectively. Comparable pH working range and selectivity pattern were observed with the PVC–based electrode. The electrode was used for determination of CHX in mouthwash and gargle, without extraction, with high precision (%RSD≤2) and accuracy (±2%). The new electrode is simple, economical and rapid when compared to the PVC–based electrode.
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