مقالههای Gholamreza Kavoosi*
توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقالههای نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده میشوند.
۱Reduction of NADH Oxidase, NO Synthase, TNF, and IL–1β mRNA Expression levels on Lipopolysacharide–Stimulated Murine Macrophages by Zataria Multiflora
اطلاعات انتشار: Molecular Biology Research Communications، دوم،شماره۳،۲۰۱۳، سال ۰
تعداد صفحات: ۱۲
Zataria multiflora (ZM) is a thyme–like aromatic plant in the Lamiaceae family that grows in central and southern Iran. ZM is extensively used as a flavor ingredient in a wide variety of foods and is used as part of popular traditional folk remedies. In the present study, ZM essential oil (ZMO) was obtained from ZM leaves via hydro–distillation and then analyzed by GC–MS (gas chromatography–mass spectrometry). The anti–inflammatory activity of ZMO was determined via measures of NADH oxidase (NOX), inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)–, and interleukin (IL)–1β mRNA expression in lipopolysaccharide–stimulated murine macrophages using real–time polymerase chain reaction (PCR). GC–MS analysis indicated that the main components in the ZMO were carvacrol (29.4%), thymol (25.7%), p–cymene (11.2%), linalool (9.3%), and γ–terpinene (8.0%). ZMO significantly reduced NOX, iNOS, TNF, and IL–1β mRNA expression in cells at concentrations of 0.1–1 μg\mL, indicating a capacity for this product to potentially modulate\diminish immune responses. ZMO has anti–oxidant and anti–inflammatory properties and could be potentially used as a safe effective source of natural anti–oxidants in therapy against oxidative damage and a number of inflammatory conditions associated with stress.
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