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۱Analgesic Activity of Carbazolealkaloid from Murraya paniculata Linn. (Rutaceae)
اطلاعات انتشار: World Applied Sciences Journal، سي و دوم،شماره۸، ۲۰۱۴، سال
تعداد صفحات: ۶
Murraya paniculata Linn. (Rutaceae) is commonly used in the treatment of pain, rheumatism diarrhoeaand dysentery. Leaves of this plant were standardized pharmacognostically. Preliminary phytochemical study of methanolic extract showed the presence Alkaloids, Flavonoids, Phenolic compounds, Phytosterols, Proteins and amino acids while saponins were absent Phytochemical studies led to isolation of alkaloid Isomurrayafoline B (Isb) and was testedat 10and 20 mg\kg p.o.for in vivo analgesic activity, peripheral as well as central pain model. Isb demonstrated 80.33% and 93.87% inhibition in the number of writhes at both doses respectively. Similarly, the thermal attenuation of Isb (20 mg\kg p.o.) was found more significant (P0.01) after 60 min of administration that remained significant upto 120 min, while Isb (10mg\kg p.o) showed significant effect (P0.01) only after 60 minutes of administration. The isolated compound showed profound analgesic activity in both peripheral and central pain models; needs further detail studies for clinical utility. In the meantime, the study validated the uses of the plant in traditional system of treatment.
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