توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Synthesis of Functionalized–Gold Nanoparticles for Targeted Drug Delivery
نویسنده(ها): ، ، ،
اطلاعات انتشار: سومین کنفرانس نانوساختارها، سال
تعداد صفحات: ۴
The chemical synthesis and in vitro drug delivery response of folate modified, polyethylene glycolfunctionalized gold nanoparticles were studied. Lysine–capped gold nanoparticles were first prepared. Subsequently the widely used anticancer agent doxorubicin (DOX) was successfully attached to the surface of folate modified, polyethylene glycol–functionalized gold nanoparticles. Fourier transform infrared spectroscopy (FTIR) and
transmission electron microscopy (TEM) were used to confirm the functionalization and conjugation steps in the chemical synthesis. The DOX–loading efficiency determined by UV–Vis spectrometer was 80%. Drug release experiments displayed a controlled–release behaviour that most of the conjugated doxorubicin was released within the first 12 h.<\div>
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