توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Maprotiline inhibits LPS–induced expression of adhesion molecules (ICAM–1 and VCAM–1) in human endothelial cells
اطلاعات انتشار: Research in Pharmaceutical Sciences، يازدهم،شماره۲(پياپي ۳۵)، ۲۰۱۶، سال
تعداد صفحات: ۷
Regardless of the known anti–inflammatory potential of heterocyclic antidepressants, the mechanisms concerning their modulating effects are not completely known. In our earlier work, maprotiline, a heterocyclic antidepressants, considerably inhibited infiltration of polymorphonuclear cell leucocytes into the inflamed paw. To understand the mechanism involved, we evaluated the effect of vascular cell adhesion molecule (VCAM–1), intracellular adhesion molecule (ICAM–1) expression in stimulated endothelial cells. Endothelial cells were stimulated with lipopolysaccharide (LPS) in the presence and absence of maprotiline (10–8 to 10–6 M) and ICAM–1 and VCAM–1 expression were measured using real–time quantitative reverse transcription polymerase chain reaction. Maprotiline significantly decreased the LPS–induced expression of VCAM–1 at all applied concentrations. The expression of ICAM–1 decreased in the presence of maprotiline at 10–6 M concentration (P0.05). Since maprotiline inhibits the expression of adhesion molecules, ICAM–1 and VCAM–1 in LPS–stimulated human endothelial cells , it can be a possible way through which maprotiline exerts its anti–inflammatory properties.
نمایش نتایج ۱ تا ۱ از میان ۱ نتیجه