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۱Omentin–1 rs2274907 and resistin rs1862513 polymorphisms influence genetic susceptibility to nonalcoholic fatty liver disease
نویسنده(ها): ، ،
اطلاعات انتشار: Molecular Biology Research Communications، پنجم،شماره۱، ۲۰۱۶، سال
تعداد صفحات: ۷
Nonalcoholic fatty liver disease (NAFLD) is an obesity–associated disease and dysregulation of adipokines has an important role in its development. Omentin–1 (ITLN1 protein) and resistin are two adipokine secreted from adipose tissue. Single nucleotide polymorphisms in the adipokine genes may affect expression and activity of the adipokine, and thus play a contributory role in NAFLD pathogenesis. The aim of the present study was to investigate the association between omentin–1 rs2274907 (326A\T) and resistin rs1862513 (–420 C\G) polymorphisms and risk of NAFLD in Iranian patients. This case–control study was done on 282 subjects included 94 patients with NAFLD and 188 healthy peoples. The genotypes were determined using PCR–RFLP method. The frequency of omentin–1 AT genotype in patients with NAFLD was significantly different from that in the control (OR=2.3, 95% CI: 1.3–3.8, P=0.003). A significant association was observed between NAFLD and the GG genotype regarding resistin rs1862513 polymorphism (OR=2.3, 95% CI: 1.1–4.8, P=0.03). In conclusion, Omentin–1 rs2274907 and resistin rs1862513 polymorphisms might be a candidate genetic factor for susceptibility to NAFLD.
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