توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Effect of five common anticonvulsant drugs on naloxone–precipitated morphine withdrawal in mice
نویسنده(ها): ،
اطلاعات انتشار: Research in Pharmaceutical Sciences، ششم،شماره۱(پياپي ۱۱)، ۲۰۱۱، سال
تعداد صفحات: ۶
This study was designed to assess the effect of five common anticonvulsant drugs on naloxone–precipitated withdrawal syndrome in morphine–dependent mice. Male mice (25–35 g) were made dependent by increasing doses of morphine (30–90 mg\kg). At least three doses of phenytoin, carbamazepine, sodium valproate, lamotrigine and topiramate were injected i.p. to morphine–dependent mice 45 min prior to induction of withdrawal syndrome by naloxone (5 mg\kg, i.p.). Control animals received vehicle. Number of jumpings was counted and ptosis, tremor, piloerection and diarrhea were checked in a 30 min period started just after naloxone injection. Results showed that lamotrigine, phenytoin and sodium valproate were ineffective in suppression of withdrawal syndrome while carbamazepine produced a dose–dependent reduction of jumpings. Topiramate at the maxium applied dose (100 mg\kg) significantly reduced number of naloxone–elicited jumpings. It seems that carbamazepine by inhibition of N–Methyl–D–Aspartate (NMDA) receptors and topiramate by inhibiting kainite–activated (AMPA) receptor antagonists suppress morphine withdrawal syndrome but further studies are needed to have a definite conclusion.
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