توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱Influence of Interleukine–1 Beta and Interleukine–1 Receptor Antagonist Genes Polymorphism on Rheumatoid Arthritis
اطلاعات انتشار: World Applied Sciences Journal، بيست و هفتم،شماره۵، ۲۰۱۳، سال
تعداد صفحات: ۱۱
Rheumatoid arthritis (RA) is a systemic autoimmune disease with different factors contributing to the etiology and pathogenesis. IL–1 has been implicated in RA and the ability of IL–1 to drive inflammation and joint erosion and to inhibit tissue repair processes has been clearly established in in vitro systems and animal models. IL–1 receptor antagonist (IL–1Ra) prevents the interaction between IL–1 and its cell–surface receptors, thus acting as a naturally occurring inhibitor. The aim of this study is to assess the role of IL–1 and IL–1Ra gene polymorphism in RA disease susceptibility and severity. The study was conducted on 50 adult RA patients and 10 controls. Results indicated that IL–1 (+3953) gene polymorphism is related to RA severity, but plays no role in RA susceptibility. It was also shown that IL–1Ra gene polymorphism (IL1RN*2) plays no role in RA susceptibility or severity. Therefore the presence of allele 2 of IL–1 gene in RA might be considered as a prognostic factor for RA.
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