توجه: محتویات این صفحه به صورت خودکار پردازش شده و مقاله‌های نویسندگانی با تشابه اسمی، همگی در بخش یکسان نمایش داده می‌شوند.
۱The Comparative Study of ECG Findings in the Patients Suffered from Subarachnoid Hemorrhage and Control Group in Northeastern Iran
اطلاعات انتشار: Journal Of Patient safety and quality improvement، سوم،شماره۲، ۲۰۱۵، سال
تعداد صفحات: ۵
Introduction: Subarachnoid Hemorrhage (SAH) which accounts for (5% to 10%) of cerebrovascular accidents is an important cause of mortality and disability. It can be complicated by many neurological and medical conditions including cardiovascular complications. During the course of SAH morphologic Electrocardiography (ECG) changes, arrhythmias, myocardial injury and elevation of cardiac enzymes, subendocardial hemorrhage and necrosis may be observed. Materials and Methods:102 SAH patients, without any history of Ischemic heart Disease (IHD), admitted in Ghaem Hospital were studied. Their clinical and radiological parameters were evaluated. Three serial ECGs were performed within the first 72 hours for each patient and the ECG findings were analyzed. The control group consisted of 102 elective patients of Ghaem hospital without any expected heart disease. Results: ECG changes were observed in 60.8% of SAH patients with average age of (53.4±14.2) years and in (2.9%) of control group. The ECG findings were as follows: chamber abnormalities (6.9%), conduction abnormalities (7.8%), repolarization abnormalities (49%), rhythm abnormalities (22.5%) and pathologic Q wave (6.9%). According to this study, ECG changes are related to subarachnoid hemorrhage (p0.01). ECG changes are independent from age and sex but they are related to clinical grading and mortality of SAH patients (P0.01). ECG changes are related to presence of intracranial aneurysm (p0.05). Conclusion: Our clinical, radiological and ECG findings are compatible with the previous studies. In this study, ECG findings in subarachnoid hemorrhage are related to the prognosis and to presence of intracranial aneurysm.

۲An Open Study of Botulinum–A Toxin Treatment of Idiopathic Trigeminal Neuralgia
اطلاعات انتشار: Journal Of Patient safety and quality improvement، سوم،شماره۳، ۲۰۱۵، سال
تعداد صفحات: ۴
Introduction: Trigeminal Neuralgia (TN) is a unilateral, recurrent, sharp facial pain disorder that is limited to the distribution of divisions of the trigeminal nerve. The aim of this study was to evaluate the efficacy of Botulinum neurotoxin type A (BTX–A) for alleviating the frequency and severity of TN pain. Materials and Methods: This trial was performed as a before and after study. We treated 31 patients (15 male and 16 female) with mean age of 52 year old that their diagnosis was made at least 4.5 years before. We injected BTX–A in various parts of face and particularly in the origin of mandibular and maxillary branches of trigeminal nerve. Injection volume was determined by the necessity and pain intensity measured with visual analog scale up to 100U. Patients were evaluated before and after the injection and were followed after week, and each month, for a three months period. Other related variables were recorded such as: toxin complications, pain status variations by brushing, chewing, cold weather and patient’s satisfaction with their therapy. Results: showed that after injection, pain intensity and frequency decreased after tooth brushing, chewing and cold weather (P0.0001). Median of pain intensity decreased from 10 to 2 in all cases. Only 6% of patients affected to transient asymmetry and other complications were not observed. After 3 months of injection 71% of patients were inclined to reinjection. Conclusion: BTX–A could be used as an effective and safe treatment method for drug resistant TN. Also it can be used in patients who are not satisfied with oral anticonvulsants.

۳Renin–Angiotensin A1166C Polymorphism and the Rrisk of Stroke
اطلاعات انتشار: Journal of Cell and Molecular Research، هفتم،شماره۱، ۲۰۱۵، سال
تعداد صفحات: ۶
Stroke is the leading cause of death and disability in the world after the cancer and cardiovascular diseases. Genetic factors have main significance to got stroke. Renin–angiotensin system contains candidate genes and polymorphisms for causing stroke. There are reported associations between stroke and angiotensin II type–1 receptor g. 1166A > C polymorphism (rs5186). Therefore in this study this association was investigated for the east Iranian population. This study is based on 201 stroke patients and 220 controls. To predict the genetic risk of stroke allele and genotype frequencies of angiotensin II type–1 receptor rs5186 were analyzed in this population according to stroke subtypes, gender, age, hypertension, diabetes mellitus, high and low density lipoprotein and triglycerides. According to statistical analysis no significant difference was found between case and control groups. But there were a significant relevance between total cholesterol and stroke (p = 0.037). In this population angiotensin II type–1 receptor g. 1166A > C polymorphism did not increase the risk of stroke. The main reason for this study is complex nature of gene–environment interactions in the pathophysiology of this disease.
نمایش نتایج ۱ تا ۳ از میان ۳ نتیجه